Meridian Health AI, a San Francisco-based startup developing artificial intelligence tools for clinical decision support, has closed a $500 million Series B funding round, making it the largest venture capital deal of 2026 to date. The round was led by Andreessen Horowitz with participation from GV, Sequoia Capital, and several major health system investment arms.
The company's platform uses large language models fine-tuned on medical literature and anonymized patient data to assist physicians with diagnosis, treatment planning, and medication management. Clinical trials at three academic medical centers showed a 25% reduction in diagnostic errors when physicians used the tool alongside their standard workflow.
Meridian plans to use the funding to expand its platform to 200 hospitals by year-end and pursue FDA clearance for its diagnostic assistance modules.
